Ultrasonography and magnetic resonance imaging changes in patients with polymyalgia rheumatica treated by tocilizumab
Identifieur interne : 001101 ( Main/Exploration ); précédent : 001100; suivant : 001102Ultrasonography and magnetic resonance imaging changes in patients with polymyalgia rheumatica treated by tocilizumab
Auteurs : Anaïs Huwart [France] ; Florent Garrigues [France] ; Sandrine Jousse-Joulin [France] ; Thierry Marhadour [France] ; Dewi Guellec [France] ; Divi Cornec [France] ; Maelenn Gouillou [France] ; Alain Saraux [France] ; Valérie Devauchelle-Pensec [France]Source :
- Arthritis Research & Therapy [ 1478-6354 ] ; 2018.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Anticorps monoclonaux humanisés (usage thérapeutique), Bursite (imagerie diagnostique), Bursite (traitement médicamenteux), Femelle, Humains, Imagerie par résonance magnétique (), Mâle, Rhumatisme inflammatoire des ceintures (imagerie diagnostique), Rhumatisme inflammatoire des ceintures (traitement médicamenteux), Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Synovite (imagerie diagnostique), Synovite (traitement médicamenteux), Échographie-doppler (), Études prospectives, Études transversales.
- MESH :
- imagerie diagnostique : Bursite, Rhumatisme inflammatoire des ceintures, Synovite.
- traitement médicamenteux : Bursite, Rhumatisme inflammatoire des ceintures, Synovite.
- usage thérapeutique : Anticorps monoclonaux humanisés.
- Adulte d'âge moyen, Femelle, Humains, Imagerie par résonance magnétique, Mâle, Résultat thérapeutique, Sujet âgé, Sujet âgé de 80 ans ou plus, Échographie-doppler, Études prospectives, Études transversales.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized (therapeutic use), Bursitis (diagnostic imaging), Bursitis (drug therapy), Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging (methods), Male, Middle Aged, Polymyalgia Rheumatica (diagnostic imaging), Polymyalgia Rheumatica (drug therapy), Prospective Studies, Synovitis (diagnostic imaging), Synovitis (drug therapy), Treatment Outcome, Ultrasonography, Doppler (methods).
- MESH :
- chemical , therapeutic use : Antibodies, Monoclonal, Humanized.
- diagnostic imaging : Bursitis, Polymyalgia Rheumatica, Synovitis.
- drug therapy : Bursitis, Polymyalgia Rheumatica, Synovitis.
- methods : Magnetic Resonance Imaging, Ultrasonography, Doppler.
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Prospective Studies, Treatment Outcome.
Abstract
This study assessed inflammatory changes using ultrasound (US) and magnetic resonance imaging (MRI) in patients taking tocilizumab for polymyalgia rheumatica (PMR).
Eighteen patients were included in the prospective open-label TENOR study and received three tocilizumab infusions, without corticosteroids. B-mode and power Doppler US and MRI (T1 and T2-short time inversion recuperation weighted sequences) of the hips and shoulders were performed at weeks 0, 2, and 12. Subacromial, trochanteric, and iliopsoas bursitis and intraarticular glenohumeral and coxofemoral effusions/synovitis were scored from 0 to 3. Changes over time and US–MRI correlations were evaluated.
At baseline, the proportions of shoulders and hips with bursitis were 93 and 100% by MRI and 61 and 13% by US; and the corresponding proportions for intraarticular effusions/synovitis were 100 and 100% by MRI and 57 and 53% by US. Imaging findings did not improve during the first two treatment weeks. From baseline to week 12, bursitis improved significantly at all four joints by MRI (
US and MRI showed significant improvements in inflammatory lesions during tocilizumab treatment of PMR.
Url:
DOI: 10.1186/s13075-017-1499-2
PubMed: 29370856
PubMed Central: 5785834
Affiliations:
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Le document en format XML
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University, Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Radiology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff5">Radiology Unit, Hôpital de Cornouaille, 14 avenue Yves Thépot, F 29000 Quimper, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Radiology Unit, Hôpital de Cornouaille, 14 avenue Yves Thépot, F 29000 Quimper</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Quimper</settlement></placeName></affiliation></author><author><name sortKey="Garrigues, Florent" sort="Garrigues, Florent" uniqKey="Garrigues F" first="Florent" last="Garrigues">Florent Garrigues</name><affiliation wicri:level="3"><nlm:aff id="Aff1">Radiology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Radiology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Jousse Joulin, Sandrine" sort="Jousse Joulin, Sandrine" uniqKey="Jousse Joulin S" first="Sandrine" last="Jousse-Joulin">Sandrine Jousse-Joulin</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff3">INSERM UMR 1227, Laboratoire d’Immunothérapie et Pathologies lymphocytaires B, Labex “Immunotherapy, Graft, Oncology”, Brest Occidentale University, 29609 Brest Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1227, Laboratoire d’Immunothérapie et Pathologies lymphocytaires B, Labex “Immunotherapy, Graft, Oncology”, Brest Occidentale University, 29609 Brest Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Marhadour, Thierry" sort="Marhadour, Thierry" uniqKey="Marhadour T" first="Thierry" last="Marhadour">Thierry Marhadour</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Guellec, Dewi" sort="Guellec, Dewi" uniqKey="Guellec D" first="Dewi" last="Guellec">Dewi Guellec</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Cornec, Divi" sort="Cornec, Divi" uniqKey="Cornec D" first="Divi" last="Cornec">Divi Cornec</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Gouillou, Maelenn" sort="Gouillou, Maelenn" uniqKey="Gouillou M" first="Maelenn" last="Gouillou">Maelenn Gouillou</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000000121866389</institution-id><institution-id institution-id-type="GRID">grid.7429.8</institution-id><institution>Clinical Investigation Centre (CIC) 1412,</institution><institution>Institut National de la Santé et de la Recherche Médicale (INSERM),</institution></institution-wrap>Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Brest</wicri:regionArea></affiliation></author><author><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff3">INSERM UMR 1227, Laboratoire d’Immunothérapie et Pathologies lymphocytaires B, Labex “Immunotherapy, Graft, Oncology”, Brest Occidentale University, 29609 Brest Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1227, Laboratoire d’Immunothérapie et Pathologies lymphocytaires B, Labex “Immunotherapy, Graft, Oncology”, Brest Occidentale University, 29609 Brest Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author><author><name sortKey="Devauchelle Pensec, Valerie" sort="Devauchelle Pensec, Valerie" uniqKey="Devauchelle Pensec V" first="Valérie" last="Devauchelle-Pensec">Valérie Devauchelle-Pensec</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Rheumatology Department, Cavale Blanche Hospital and Brest Occidentale University, Brest</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="Aff3">INSERM UMR 1227, Laboratoire d’Immunothérapie et Pathologies lymphocytaires B, Labex “Immunotherapy, Graft, Oncology”, Brest Occidentale University, 29609 Brest Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 1227, Laboratoire d’Immunothérapie et Pathologies lymphocytaires B, Labex “Immunotherapy, Graft, Oncology”, Brest Occidentale University, 29609 Brest Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author></analytic><series><title level="j">Arthritis Research & Therapy</title><idno type="ISSN">1478-6354</idno><idno type="eISSN">1478-6362</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antibodies, Monoclonal, Humanized (therapeutic use)</term><term>Bursitis (diagnostic imaging)</term><term>Bursitis (drug therapy)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Polymyalgia Rheumatica (diagnostic imaging)</term><term>Polymyalgia Rheumatica (drug therapy)</term><term>Prospective Studies</term><term>Synovitis (diagnostic imaging)</term><term>Synovitis (drug therapy)</term><term>Treatment Outcome</term><term>Ultrasonography, Doppler (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Anticorps monoclonaux humanisés (usage thérapeutique)</term><term>Bursite (imagerie diagnostique)</term><term>Bursite (traitement médicamenteux)</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique ()</term><term>Mâle</term><term>Rhumatisme inflammatoire des ceintures (imagerie diagnostique)</term><term>Rhumatisme inflammatoire des ceintures (traitement médicamenteux)</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Synovite (imagerie diagnostique)</term><term>Synovite (traitement médicamenteux)</term><term>Échographie-doppler ()</term><term>Études prospectives</term><term>Études transversales</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antibodies, Monoclonal, Humanized</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Bursitis</term><term>Polymyalgia Rheumatica</term><term>Synovitis</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bursitis</term><term>Polymyalgia Rheumatica</term><term>Synovitis</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Bursite</term><term>Rhumatisme inflammatoire des ceintures</term><term>Synovite</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term><term>Ultrasonography, Doppler</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Bursite</term><term>Rhumatisme inflammatoire des ceintures</term><term>Synovite</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Anticorps monoclonaux humanisés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Imagerie par résonance magnétique</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Échographie-doppler</term><term>Études prospectives</term><term>Études transversales</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">This study assessed inflammatory changes using ultrasound (US) and magnetic resonance imaging (MRI) in patients taking tocilizumab for polymyalgia rheumatica (PMR).</p></sec><sec><title>Methods</title><p id="Par2">Eighteen patients were included in the prospective open-label TENOR study and received three tocilizumab infusions, without corticosteroids. B-mode and power Doppler US and MRI (T1 and T2-short time inversion recuperation weighted sequences) of the hips and shoulders were performed at weeks 0, 2, and 12. Subacromial, trochanteric, and iliopsoas bursitis and intraarticular glenohumeral and coxofemoral effusions/synovitis were scored from 0 to 3. Changes over time and US–MRI correlations were evaluated.</p></sec><sec><title>Results</title><p id="Par3">At baseline, the proportions of shoulders and hips with bursitis were 93 and 100% by MRI and 61 and 13% by US; and the corresponding proportions for intraarticular effusions/synovitis were 100 and 100% by MRI and 57 and 53% by US. Imaging findings did not improve during the first two treatment weeks. From baseline to week 12, bursitis improved significantly at all four joints by MRI (<italic>P</italic> = 0.005) and US (<italic>P</italic> = 0.029) and intraarticular effusions/synovitis by US only (<italic>P</italic> = 0.001). The proportion of abnormalities that improved by week 12 was 42% by MRI and 37% by US. MRI detected bursitis in a larger proportion of hips (73% versus 13%) and US in a larger proportion of shoulders (57% versus 28%), whereas no difference was found for intraarticular effusions/synovitis. At baseline, agreement between US and MRI findings was poor.</p></sec><sec><title>Conclusions</title><p id="Par4">US and MRI showed significant improvements in inflammatory lesions during tocilizumab treatment of PMR.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dasgupta, B" uniqKey="Dasgupta B">B Dasgupta</name></author><author><name sortKey="Salvarani, C" uniqKey="Salvarani C">C Salvarani</name></author><author><name sortKey="Schirmer, M" uniqKey="Schirmer M">M Schirmer</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Li, Cdb" uniqKey="Li C">CDB Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Izumi, K" uniqKey="Izumi K">K Izumi</name></author><author><name sortKey="Kuda, H" uniqKey="Kuda H">H 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last="Garrigues">Florent Garrigues</name><name sortKey="Gouillou, Maelenn" sort="Gouillou, Maelenn" uniqKey="Gouillou M" first="Maelenn" last="Gouillou">Maelenn Gouillou</name><name sortKey="Guellec, Dewi" sort="Guellec, Dewi" uniqKey="Guellec D" first="Dewi" last="Guellec">Dewi Guellec</name><name sortKey="Huwart, Anais" sort="Huwart, Anais" uniqKey="Huwart A" first="Anaïs" last="Huwart">Anaïs Huwart</name><name sortKey="Jousse Joulin, Sandrine" sort="Jousse Joulin, Sandrine" uniqKey="Jousse Joulin S" first="Sandrine" last="Jousse-Joulin">Sandrine Jousse-Joulin</name><name sortKey="Jousse Joulin, Sandrine" sort="Jousse Joulin, Sandrine" uniqKey="Jousse Joulin S" first="Sandrine" last="Jousse-Joulin">Sandrine Jousse-Joulin</name><name sortKey="Marhadour, Thierry" sort="Marhadour, Thierry" uniqKey="Marhadour T" first="Thierry" last="Marhadour">Thierry Marhadour</name><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name><name sortKey="Saraux, Alain" sort="Saraux, Alain" uniqKey="Saraux A" first="Alain" last="Saraux">Alain Saraux</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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